【学术前沿】相分离专辑|Membraneless Organelle Dynamics and C…

以下文章来源于JMCB科学前沿 ，作者JMCB编辑部

JMCB科学前沿

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近年来，科学家们发现细胞内呈现出大量以液滴形式存在的无膜细胞器（membraneless organelles），这些无膜细胞器通过生物分子的液–液相分离（liquid–liquid phase separation，LLPS）形成，它们能够响应胞外信号，从而调控细胞可塑性。无膜细胞器不仅可以作为信号级联放大反应的组织中心，还可以作为信号催化过程的纳米反应器。无膜细胞器的组装被细胞内环境严格调控，若调控紊乱，将导致蛋白质错误折叠和凝集，扰乱细胞可塑性并引发疾病。为推动这一领域的发展，探究更多细胞生物学的未解之谜，本期专辑将为您解读无膜细胞器动力学的分子机制、以及它与细胞可塑性之间的调控关系。

Membraneless Organelle Dynamics

and Cell Plasticity

Editorial│Orchestration of cell plasticity by phase separation

Associate Editor: Xuebiao Yao

Review│Mechanisms and regulation underlying membraneless organelle plasticity control

First Author: Hazrat Ismail

Corresponding Authors:

Xing Liu, Xuebiao Yao

Keywords:

liquid–liquid phase separation, membraneless organelles, biomolecular condensates, intrinsically disordered proteins, post-translational modifications

Review│Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2

Authors: Viviana Scoca, Francesca Di Nunzio

Keywords:

LLPS, MLO, HIV-1, SARS-CoV-2

Review│Regulation of nonsense-mediated mRNA decay in neural development and disease

First Authors:

Paul Jongseo Lee，Suzhou Yang

Corresponding Author: Junjie U. Guo

Keywords:

RNA metabolism, nonsense-mediated mRNA decay, neurodegeneration, neurodevelopment, amyotrophic lateral sclerosis, frontal temporal dementia, mRNA translation

Article│Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

First Author: Maarten C. Hardenberg

Corresponding Authors:

Tessa Sinnige, Michele Vendruscolo

Keywords:

α-synuclein, liquid‒liquid phase separation, Parkinson's disease

Article│LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency

First Authors: Pixi Yan, J. Yuyang Lu

Corresponding Authors:

Yafei Yin, Xiaohua Shen

Keywords:

lncRNA, Platr22, super-enhancer, pluripotency

Perspective│Phase separation, transcriptional elongation control, and human diseases

First Author: Chenghao Guo

Corresponding Authors:

Zhuojuan Luo, Chengqi Lin

Perspective│Membrane-associated phase separation: organization and function emerge from a two-dimensional milieu

Author: Jonathon A. Ditlev

Letter to the Editor│Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution

First Author: Xiao-Min Liu

Corresponding Authors:

Xiao-Min Liu, Jun Zhou

关于JMCB

Journal of Molecular Cell Biology (JMCB) 创刊于2009年10月，由中国科学院主管，由中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）和中国细胞生物学学会共同主办，与牛津大学出版社 (Oxford University Press，OUP) 合作出版，为完全开放获取期刊，聚焦分子细胞生物学前沿进展及相关多学科交叉研究，2020年度影响因子为6.216，5年影响因子为6.688。

来源：JMCB科学前沿

原标题：《【学术前沿】相分离专辑|Membraneless Organelle Dynamics and Cell Plasticity》

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