CCS Chemistry 2021年第八期主编寄语——世界激励科学前进，科学推动世界发展

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“You cannot hope to build a better world without improving the individuals. To that end, each of us must work for our own improvement.”

- 玛丽·居里，1903及1911 诺贝尔奖获得者

今年北半球入夏以来，极端天气侵袭多国，多地最高气温突破以往纪录。例如6月底加拿大不列颠哥伦比亚省出现了令人震惊的近50°C的高温，这是加国最高温度的记录，导致480多名居民死亡。在美国俄勒冈州达到了46.6°C的历史最高水平，科威特和伊朗今年夏天到目前为止都有超过51°C的记录，今年有23个国家的最高气温达到了50°C甚至更高。

极端高温给世界的多个地区造成了毁灭性的破坏，而另一些地区则遭受了严重的洪水，造成了山体滑坡、大面积破坏和数百人死亡。中国、德国、英国、比利时、荷兰、印度、澳大利亚等许多国家都遭受了暴雨和严重洪涝灾害。

根据科学家们利用空气温度、海平面温度、海平面高度及其它基于空间观测的最新测量数据， 2020年是地球有记录以来第二温暖的一年(“冠军”是2016年)。兰州大学最近的一项研究显示，地球冰冻圈自1979年至2016年间平均每年缩小约8.7万平方公里[1]。科学家们已经开发了许多模型来预测温度变化对天气模式的影响。瑞士研究人员最近在Nature Climate Change杂志上发表的一项研究预测[2]，“……在未来几十年内，不仅会发生更强烈的极端气候事件，而且还会打破以往记录……。”

应对气候变化问题的一种方法是发展清洁能源技术，这已成为国际间备受瞩目的话题。在 CCS Chemistry 上发表的许多文章，包括本月刊中的几篇，都是介绍了推动全球清洁能源优先发展的技术前沿成果。本期重点介绍的其他研究还包括增强对疾病和人类健康理解的发现等。本期共有 24 篇文章，其中包括 1 篇迷你评论、6 篇通讯和 17 篇研究文章，以下是每篇文章的简短推荐：

-Molecular/Ionic Superfluid. Lei Jiang (江雷) and coworkers demonstrate that the driving force of molecular/ionic superfluid formation is the attraction–repulsion balance of particles under the influence of interfacial confinement, as well as the space-confinement effect, leading to a reduction in degrees of freedom of the particles and limiting disordered movement. The concept of superfluidity may help to understand the ultrafast charging–discharging processes of batteries and supercapacitors, and inspire the fabrication of high-performance materials for energy.

-High-Pressure Physical Chemistry. Two-dimensional perovskites have attracted considerable interest for use in optoelectronic applications. Bo Zou（邹勃）, Kai Wang（王凯） and coworkers disclose the distinct piezochromism of a perovskite, (HO(CH2)2NH3)2PbI4, which exhibits a red shift of photoluminescence from the initial 542 nm to 674 nm at 9.2 GPa. The achieved narrow emission with high color purity is favorable for applications of perovskites at extreme conditions.

-Water Stability of MOF. Water instability of many metal–organic frameworks (MOF) is considered to be a major challenge in practical applications. Hai-Long Jiang（江海龙） and Meili Ding（丁美丽） demonstrate a general approach to address this problem by coating a thin hydrophobic polymer on the external surface of a MOF. The modified MOF exhibits enhanced structural stability and good recyclability for catalyzing organic reactions in water.

-Switchable Protein Nanocages. Protein-based nanocontainers as ideal mimics of natural viral structures and functions continue to attract the interest of chemists. Qiang Yan（闫强） and coworkers present a new strategy to assemble switchable protein nanocages based on allosterically-activated protein–ligand interactions, offering a new prospect of building dynamic and smart virus mimics.

-Nonfullerene Organic Solar Cells. Zhaohui Wang(王朝晖), He Yan（颜河）, Dong Meng（孟冬） and coworkers report two isomeric perylene diimide-fused corannulene acceptors, CRP-1 and CRP-2, which display strong absorption and match energy levels with the P3TEA donor polymer. An organic solar cell (OSC) based on CRP-1:P3TEA blend exhibits a power conversion efficiency of 11.2%, which is the highest efficiency for perylene diimide-based OSC reported to date.

-POM-Catalyzed Hydrogen Evolution. Guo-Yu Yang（杨国昱）, Zhong-Ling Lang（郎中玲）, Hongjin Lv（吕红金） and coworkers report a novel mixed-valence, ring-shaped Mn-containing polyoxometalate (POM), which is composed of four {MnIII3MnIV(PW9)} subunits connected by four PO4 linkers. A three-component system containing this POM exhibits high catalytic activity for visible-light-driven hydrogen evolution.

-Benzylic C–H Thiocyanation. Benzyl thiocyanates are an important structural motif in bioactive molecules as well as a versatile synthetic intermediate. Guosheng Liu（刘国生） and coworkers develop an efficient method for benzylic C–H bond thiocyanation via copper-catalyzed radical relay. It is worth noting that both benzyl isothiocyanates and thioureas can be obtained from associated C–H substrates in a successive one-pot fashion.

-Supramolecular Combination Chemotherapy. Xi Zhang（张希）, Yu Yi（易宇）, Hao Wang（王浩） and coworkers successfully establish a nanoparticle-based strategy of supramolecular combination chemotherapy for overcoming the drug resistance of cancer cells. The cucurbit[7]uril-containing polymer efficiently encapsulate synergetic chemical drugs like oxaliplatin and bioactive peptide drugs in a precise dosage ratio, and the drugs can be released in a controlled manner in cases of tumor acidity.

-Regioselective Synthesis of Indanones. The insertion of an olefin into a C–C single bond, referred to as the “cut and sew” transformation, has recently drawn special attention. Hao Wei （魏颢）and coworkers present two selective carboacylation transformations of 2-styryl ketones, in which the nickel and rhodium catalysts are employed to control regioselectivity, leading to 2- and 3-substituted indanones, respectively.

-Oxygen Reduction Catalyst. To address the relatively poor oxygen reduction reaction (ORR) performance of conventional Pd catalysts, Xiaoqing Huang（黄小青） and coworkers synthesize a class of H-implanted Pd nanocrystals (NCs) with optimized electronic structures. All shaped H-implanted Pd NCs display increased ORR activities compared with the corresponding pristine Pd NCs, with the H-implanted Pd icosahedra/C performing the best.

-Imaging and Therapy for Colon Cancer. Guosheng Song（宋国胜） and coworkers fabricate Gd/Cu-nanosheets, which can be disassembled into Gd-porphyrin upon reaction with H2S secreted by colon cancer cells. Gd/Cu-nanosheets can be employed in both bimodal MRI/fluorescence imaging and efficient photodynamic therapy of colon cancer in vivo with minimization of toxicity toward normal tissues.

-Polymer Single-Chain Nanoparticles. Polymer single-chain nanoparticles (SCNPs) are a new class of nanomaterials. Hu-Jun Qian（钱虎军）, Huanyu Zhao（赵环宇） and coworkers develop a facile strategy to synthesize SCNPs with controllable folding, which is achieved by intrachain cross-linking of N-isopropylacrylamide-based copolymers with prefolded conformations. These thermoresponsive SCNPs may be superior candidates for applications in drug cargo systems.

-Intracellular MicroRNA Imaging. Jing-Juan Xu（徐静娟）, Xiang-Ling Li（李向玲） and coworkers design an integrated DNA motor–MnO2 nanocomposite for sensitive imaging of microRNAs in living cells. Combining the reduction of MnO2 nanosheets with the in situ magnification of DNA motors, the nanocomposite displays selective imaging of intracellular microRNA with lower background fluorescence and self-powered performance.

-MOF-Based Fluorescent Sensors. Cheng Wang（汪成） and coworkers synthesize a series of metal–organic frameworks (MOF) with variable ligand ratios of FRET donor to acceptor. Since the reduction of the acceptor limits the FRET process, these MOFs can be used as fluorescent turn-on sensors for a reductive analyte, providing a new approach to construct fluorescence sensing materials with a remarkable amplification effect.

-Ratiometric Fluorescent Probe for Bioimaging. Youjun Yang（杨有军）, Xiaowen Liang(梁晓雯), Wen Yang（杨文）, Xiao Luo （罗潇）and coworkers design and synthesize a ratiometric fluorescent probe by changing the bridging group of xanthenoid dyes. The probe can be applied to monitor the total cellular oxidative capacity with no probe–product crosstalk, exhibiting higher detection sensitivity and photostability than two commercial probes.

-Polynuclear Gold(I) Complexes. Vivian Wing-Wah Yam（任詠华） and coworkers disclose an unprecedented cluster-to-cluster transformation of polynuclear gold(I)-sulfido complexes, which is attributed to the effect of substituent groups on electron density of a metal center. This novel synthetic pathway may be useful in developing polynuclear gold complexes with rich luminescence properties.

-Electrochemical Synthesis. Synthesizing medium-sized nitrogen heterocycles remains a significant challenge. Aiwen Lei （雷爱文）and coworkers develop a practical protocol for electrochemical synthesis of medium-sized lactams from commercially available benzocyclic ketones and amides. This transformation features excellent tolerance to highly electron-rich and electron-deficient moieties.

-Flexible Transparent Electrode. Huan Liu （刘欢）and coworkers fabricate a flexible transparent electrode (FTE) by solution coating of silver nanowires from orthogonal directions, in which a conical fiber array provides good guidance for the alignment of the nanowires. A high-performance transparent quantum dot light-emitting diode device has been achieved owing to the high conductivity and transparency of the FTE materials.

-Polymerization-Induced Cooperative Assembly. Particles with ordered inverse mesophases have shown a great promise in biomaterials, nanotemplates, and bioreactors. Zesheng An（安泽胜）, Peiyi Wu（武培怡） and Fei Lv employ polymerization-induced cooperative assembly (PICA) to prepare particles with inverse bicontinuous mesophases, demonstrating that PICA is more effective to access these rare morphologies than polymerization-induced self-assembly.

-G-Quadruplex-DNAzymes. Improvement of the activities of G-quadruplex (G4) DNAzymes is of particular interest. Jun Zhou（周俊）, Huangxian Ju（鞠熀先）, Célia Fonseca Guerra and coworkers design a series of parallel G4s and investigate the influence of various proximal cytosine derivatives on their catalytic performances. To design a high-activity DNAzyme, they propose several necessary characteristics for adjacent nucleotides, including high electron density.

-Dual Functionalization of Phenols. Albert S. C. Chan（陈新滋）, Shan-Shui Meng（孟山水）, Gaofei Wei （卫高菲）and coworkers disclose a borane-catalyzed dual functionalization of unprotected phenols with α- or β-hydroxy acids. Various benzofuranones and dihydrocoumarins are obtained in moderate to good yields. The synthetic application of this reaction has been demonstrated in gram-scale experiments and one-pot synthesis of an antioxidant.

-Spin-State Switch of Fe(II) Complex. Xin Bao（暴欣） and coworkers synthesize an Fe(II) complex with a rhodamine B 2-pyridinecarbaldehyde hydrazine ligand. Upon alternating acidification and alkalization treatments, the complex exhibits reversible spin-state switching at room temperature owing to pH-dependent coordination, which is accompanied by a significant fluorescence change.

-Alzheimer’s Disease Therapy. Yang Liu（刘阳） and coworkers design a nanoscavenger that can penetrate the blood–brain barrier and induce the co-aggregation with neurotoxic soluble β-amyloid aggregates through multivalent interactions. The co-aggregation facilitates β-amyloid clearance by microglia via antibody-dependent cell-mediated phagocytosis, providing a novel strategy for effective Alzheimer’s disease therapy.

-Ion Transport by Molecular Tetrahedrons. A conventional ion-relay mechanism for ion transport requires three or more relay stations to fully span the hydrophobic membrane region. Huaqiang Zeng （曾华强）and coworkers describe a novel strategy, incorporating a swing action to realize an ion-relay mechanism via only two relay stations. This unconventional two-station swing-relay mechanism is achieved by using a class of crown-ether-appended, long-armed molecular tetrahedrons.

CCS Chemistry的每一期都是一个探索和了解世界范围内化学和化学科学领域最具影响力研究工作的新机会。每期的规模不大，每一篇工作的简明总结也会附上，希望您能抽空阅览，发现一些本专业领域内外有趣的研究。我们不知道灵感可能藏在哪里，或许CCS Chemistry上的一篇文章可能会带给您一点想法，帮助到您的研究。

作为科学家，我们努力正在通过自己的研究和日常行动，尽所能地让世界变得更加美好。正如居里夫人曾言, “You cannot hope to build a better world without improving the individuals. To that end, each of us must work for our own improvement.” “First principle: never to let one’s self be beaten down by persons or by events.” 新冠病毒 (COVID-19)和极端天气带来的动荡和破坏，使全球面临巨大挑战。遵从居里博士的建议，只有通过力量、决心和自我完善，我们才能克服这些挑战。而且，在这个过程中，对未来产生积极影响的伟大研究也会应势而出——无论是在健康、清洁能源、农业、技术、环保或其他领域。

CCS Chemistry欢迎化学相关各个领域的研究成果， Author Spotlight 栏目还会重点聚焦我们的作者。相互学习、交流彼此的研究成果和经验非常重要。如果您有一个杰出的研究成果，请考虑提交给CCS Chemistry! 我们将在全球推广您的文章，并欢迎您在作者聚焦系列中与世界分享您的科研故事。

张希 教授

CCS Chemistry常务副主编

E-mail: xi@tsinghua.edu.cn

Donna J. Minton 博士

中国化学会出版主管

E-mail: donna.minton@chinesechemsoc.org

参考文献：

[1]. Peng, X.; Zhang, T.; Frauenfeld, O. W.; Du, R.; Jin, H.; Mu, C. A Holistic Assessment of the 1979-2016 Global Cryospheric Extent. Earth’s Future 2021, 9. https://doi.org/10.1029/2020EF001969

[2]. Fischer, E. M.; Sippel, S; Knutti, R. Increasing Probability of Record-Shattering Climate Extremes. Nat. Clim. Chang. 2021. https://doi.org/10.1038/s41558-021-01092-9.

注：本文根据CCS Chemistry 2021年第八期editorial 翻译整理而成，原文请见：https://doi.org/10.31635/ccschem.021.202100730ed1。

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原标题：《CCS Chemistry 2021年第八期主编寄语——世界激励科学前进，科学推动世界发展》

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