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CCS Chemistry 2023年第12期上线

2023-12-06 10:54

来源：澎湃新闻·澎湃号·政务

以下文章来源于CCSChemistry ，作者CCS Chemistry

CCSChemistry.

CCS Chemistry是由中国化学会创办的高水平旗舰新刊，面向全球科学家，收录化学各领域高质量原创科技论文。关注CCS Chemistry，即时获取期刊相关资讯。

CCS Chemistry 2023年第12期上线！本期特别推出“Precise Construction of Multi-level Chiral Substances”专题，包含 4 篇Mini Reviews和3篇Research Articles，介绍和总结了多层次、跨尺度手性物质（如小分子手性化合物、手性超分子和手性材料）研究领域的最新进展，展望了手性物质研究的未来发展和挑战。

除专题外，本期还收录了13篇Research Articles，涵盖环张力释放驱动的糖基化、团簇发光、表面手性纳米石墨烯、室温磷光材料、聚合物太阳能电池和聚合物解聚等方面最新研究进展。

了解更多信息，欢迎访问：https://www.chinesechemsoc.org/toc/ccschem/5/12。免费阅读下载整期文章。

2023年第12期

Author Spotlight

本期Author Spotlight邀请了英国伦敦大学学院/清华大学唐军旺、新加坡南洋理工大学Mihaiela C. Stuparu、武汉大学田沺、澳大利亚昆士兰科技大学许景三、湖南大学刘艳岚五位老师，分享自己科研经历中独特的心得和感悟。

Link：https://doi.org/10.31635/ccschem.023.202301129ed2

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以下是本期每篇文章的导读和阅读链接（标星号*为“Precise Construction of Multi-level Chiral Substances”特别专题文章）：

*-Asymmetric Catalysis. Asymmetric catalysis is the most commonly used method for the enantioselective synthesis of small chiral organic molecules. In this review, Qing-Hua Fan (范青华), Shu-Li You (游书力), Sanzhong Luo (罗三中), Shou-Fei Zhu (朱守非), Xue-Feng Fu (付雪峰), Qi-Lin Zhou (周其林), and coworkers introduce the latest research progress of asymmetric catalysis in China from several perspectives: the development of new chiral ligands, transition-metal-catalyzed asymmetric reactions, asymmetric organocatalytic reactions, and new strategies for asymmetric catalysis. A brief outlook on the development of novel chiral ligands/catalysts, new enantioselective reactions, and their applications in chiral drugs and agricultural chemicals is also provided.

Cite this: CCS Chem. 2023, 5, 2685-2716

Link: https://doi.org/10.31635/ccschem.023.202303347

更多阅读：综述推荐 | 中国不对称催化研究最新进展

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*-Ligand Acceleration. Understanding the phenomenon of ligand acceleration in asymmetric catalysis provides a great impetus not only for improving existing asymmetric catalytic reactions, but also for developing new ones. In this review, Xiaohua Liu (刘小华), Xiaoming Feng (冯小明), and coworkers present several examples of ligand acceleration in Lewis acid-catalyzed asymmetric reactions. The importance of chiral ligands on solubility, aggregation state, geometry, Lewis acidity, and photophysical properties of metal salts are addressed, with the goal that there is increased appreciation of the role of ligands in the development of new efficient ligands and asymmetric reactions.

Cite this: CCS Chem. 2023, 5, 2717-2735

Link: https://doi.org/10.31635/ccschem.023.202303417

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*-Chiral Supramolecules. Rational design and hierarchical assembly of chiral supramolecules are core development areas in the study of many complex functions, including chiral recognition, enantioselective separation, asymmetric catalysis, circularly polarized luminescence, and enantioselective transmembrane transport. In this review, Jinqiao Dong (董金桥), Xiangcheng Pan (潘翔城), Yan Liu (刘燕), Hai-Bo Yang (杨海波), Xuefeng Fu (付雪峰), Yong Cui (崔勇), and coworkers provide an overview of chiral supramolecules with different lengths and scales that were developed by Chinese researchers in recent years. The design, synthesis, structure and application of well-defined, cavity-containing chiral subjects, chiral polymers, and chiral crystal frame materials are addressed, as well as a look at some challenges and potential growth areas in the field.

Cite this: CCS Chem. 2023, 5, 2736-2759

Link: https://doi.org/10.31635/ccschem.023.202303348

更多阅读：综述推荐 | 中国多层次手性组装研究的最新进展

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*-Circularly Polarized Luminescence. Chiral materials have many unique properties and important potential applications. Among the properties of chiral materials, circularly polarized luminescence has attracted the most attention. In this review, You-Xuan Zheng (郑佑轩), Hua Kuang (匡华), Chuan-Feng Chen (陈传峰), Minghua Liu (刘鸣华), Pengfei Duan (段鹏飞), Zhiyong Tang (唐智勇), and coworkers summarize the latest research progress on circularly polarized luminescence in China, including organic, inorganic, and hybrid materials. An emphasis is placed on the development of chiral emissive materials and their applications in displays, organic lasers, anti-counterfeiting measures, and sensors.

Cite this: CCS Chem. 2023, 5, 2760-2789

Link: https://doi.org/10.31635/ccschem.023.202303346

更多阅读：综述推荐 | 中国手性发光材料研究的最新进展

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*-Chemodivergent Synthesis. Divergent synthesis is an effective strategy that allows compounds with diverse structures to be quickly synthesized. Zheng Wang (王正), Kuiling Ding (丁奎岭), and coworkers demonstrate a palladium-catalyzed chemodivergent regio- and enantioselective allylic alkylation of 4- or 5-substituted oxazol-2(3H)-ones with Morita–Baylis–Hillman adducts. The method can be readily performed with high yields on the gram scale under relatively low catalyst loading.

Cite this: CCS Chem. 2023, 5, 2790-2798

Link: https://doi.org/10.31635/ccschem.023.202303249

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*-Glycosylation Reaction. Stereoselective glycosylation is the basis of polysaccharide synthesis and is also the focus of carbohydrate chemistry research. Liming Zhang (张立明) and coworkers developed a gold-catalyzed SN2 glycosylation method with high stereoselectivity for the synthesis of 2-azido-2-deoxyglucosides and 2-azido-2-deoxygalactosides. The utility of their approach is demonstrated in the synthesis of a trisaccharide featuring three 1,2-cis-2-azido-2-deoxyglycosidic linkages.

Cite this: CCS Chem. 2023, 5, 2799-2807

Link: https://doi.org/10.31635/ccschem.023.202303086

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*-Asymmetric Hydrogenation. Tetra-substituted olefins are challenging substrates in asymmetric hydrogenation. Shao-Fei Ni (倪绍飞), Shao-Tao Bai (白绍涛), Xumu Zhang (张绪穆), and coworkers report an Ir-catalyzed asymmetric hydrogenation of tetra-substituted exocyclic olefins, producing chiral cyclic β-amino esters with high yield and excellent enantioselectivity and diastereoselectivity. Application on the gram-scale of dexmethylphenidate was also demonstrated, showing the potential of Ir-catalyzed enantioselective hydrogenation in drug synthesis.

Cite this: CCS Chem. 2023, 5, 2808-2817

Link: https://doi.org/10.31635/ccschem.023.202202601

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-Plastic Recycling. Polyethylene terephthalate (PET) recycling is a challenging task due to the lack of efficient and cost-effective depolymerization methods. Junwang Tang (唐军旺) and coworkers develop a microwave catalytic depolymerization method for PET recycling using modified zinc oxide loaded with manganese oxide as a cocatalyst. The modified Mn3O4/ZnO catalyst exhibits high efficiency in depolymerizing PET at 175 °C, resulting in 100% conversion of PET and 88% selectivity toward bis-hydroxyethyl terephthalate monomers. In addition, the heterogeneous nature of the catalyst facilitates the catalyst recovery process, enabling cost-effective PET recycling.

Cite this: CCS Chem. 2023, 5, 2818-2831Link: https://doi.org/10.31635/ccschem.023.202303089

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-Clusteroluminescence. Nonconjugated clusteroluminogens have historically been ignored because of their weak visible emissions in the aggregate state. Haoke Zhang (张浩可), Jing Zhi Sun (孙景志), Feihe Huang (黄飞鹤), Ben Zhong Tang (唐本忠), and coworkers present a general strategy to construct nonconjugated clusteroluminogens by precisely regulating the intramolecular through-space interaction to improve their photophysical properties. The rational guidelines gained from these investigations are anticipated to provide new insights into clusteroluminescence mechanisms.

Cite this: CCS Chem. 2023, 5, 2832-2844

Link: https://doi.org/10.31635/ccschem.023.202302815

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-Dilution Accelerated Crystallization. Chemical reactions in homogenous systems are generally associated with positive-order kinetics, wherein the reaction rate increases with the increased concentration of reactants. Peng Meng, Jingsan Xu (许景三), and coworkers report a coordination reaction of Cu2+ ions, cyanuric acid, and pyridine in aqueous solution which shows negative-order kinetics with respect to pyridine concentration. Their results highlight the critical role of concentrations in multicomponent systems and deepen the understanding of competitive interplay of multiple interactions in chemistry.

Cite this: CCS Chem. 2023, 5, 2845-2854

Link: https://doi.org/10.31635/ccschem.023.202303095

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-Flexible Optoelectronic Devices. Flexible transparent electrodes have been widely used in making flexible optoelectronic devices. Huan Liu (刘欢) and coworkers develop a facile liquid-bridge assisted Couette-flow solution process for aligning silver nanowires into a highly ordered horizontal array over a large area. The alignment deviation is significantly smaller than those made by other solution processes. Furthermore, a highly cross-aligned silver nanowire network has been fabricated, leading to a high-performance flexible transparent electrode with high conductivity, long lifetime, and good adhesion-stability.

Cite this: CCS Chem. 2023, 5, 2855-2865

Link: https://doi.org/10.31635/ccschem.023.202302694

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-Room-Temperature Phosphorescence Materials. Dongpeng Yan (闫东鹏) and coworkers synthesize one-dimensional crystalline microrods of an organic–inorganic hybrid metal halide, L-ZnCl4, which shows ultralong room-temperature phosphorescence and acts as a photochromic optical waveguide with high reversibility and a large switching ratio. The bright blue fluorescence and orange afterglow are easily recognized in the pristine microrod L-ZnCl4, while the emission colors change to cyan and green upon UV irradiation. Based on emission tunability, multicolor photonic barcodes for data encryption have been fabricated.

Cite this: CCS Chem. 2023, 5, 2866-2876

Link: https://doi.org/10.31635/ccschem.023.202202605

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-Photosensitizer Nanoparticles. Photodynamic therapy (PDT) has emerged as an efficient treatment for cancers in recent years. However, PDT is limited by low utilization of photosensitizers and tumor hypoxia. The short lifetime and diffusion radius of singlet oxygen further decrease the anticancer effect of PDT. Jie Zhao (赵洁), Junbai Li (李峻柏), and coworkers design and synthesize diameter-controllable photosensitizer nanoparticles which can specifically accumulate on the mitochondria of cancer cells and increase the O2 concentrations nearby to enhance PDT efficacy.

Cite this: CCS Chem. 2023, 5, 2877-2887

Link: https://doi.org/10.31635/ccschem.023.202202525

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-Novel Nanographene. As the molecular dimensions and structural complexity of nanographenes increase, the challenge to characterize the molecular structure increases as well. Lifeng Chi (迟力峰), André Schirmeisen, Mihaiela C. Stuparu, and coworkers report a new method for synthesizing a highly distorted propeller-shaped novel nanographene. The chirality of its nanostructure at the surface is visualized directly at the single-molecule level by scanning probe microscopies. They show that submolecular resolution imaging by AFM/STM is a powerful real-space tool for the stereochemical characterization of three dimensional nanographene structures.

Cite this: CCS Chem. 2023, 5, 2888-2896

Link: https://doi.org/10.31635/ccschem.023.202303065

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-Molecular Senomorphics. Specific regulation of the senescence-associated secretory phenotype is vital to block senescence-induced detrimental cellular plasticity. Compounds called senomorphics have demonstrated such potential, but it remains challenging to achieve site-specific activation and real-time monitoring of the action of senomorphics. Yanlan Liu (刘艳岚) and coworkers report a tailor-made hydrogen sulfide (H2S) donor (Lyso-FH2S-Gal) as a new class of molecular senomorphics for spatially controlled delivery of H2S for visualization of regulation of cellular senescence. It offers a useful molecular tool with the hope for controlled intervention of senescence-related important biological processes.

Cite this: CCS Chem. 2023, 5, 2897-2909

Link: https://doi.org/10.31635/ccschem.023.202302714

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-Strain-Release-Enabled Glycosylation. Xiong Xiao (肖雄), Xue-Wei Liu (刘学伟), and coworkers develop a novel donor–acceptor cyclopropane/Sc(OTf)3 system for activating thioglycoside donors and promoting efficient glycosylation of structurally diverse acceptors, in which the activation process is driven by the strain release of the donor–acceptor cyclopropane. Furthermore, the one-pot assembly of linear and branched trisaccharides demonstrates potential applications of this activation method in the syntheses of complex oligosaccharides and natural glycosides.

Cite this: CCS Chem. 2023, 5, 2910-2921

Link: https://doi.org/10.31635/ccschem.023.202202671

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-Fluorescence Sensors. Innovative design of sensing fluorophores possessing superior photophysical properties and packing-resistance structures is pivotal for high-performance fluorescent film sensors. Jiani Ma (马佳妮), Pi-Tai Chou (周必泰), Yu Fang (房喻), and coworkers design a new series of di-o-carborane derivatives of perylene monoimide (PMI), including PDCB and PDCBP. PDCB possesses a rigid and V-shaped structure, which shows not only PMI-like emission but also a solvent-dependent emission in the red and infrared regions. Moreover, a PDCB-based tubular sensor has been fabricated for the high-performance detection of acetone vapor.

Cite this: CCS Chem. 2023, 5, 2922-2932

Link: https://doi.org/10.31635/ccschem.023.202202664

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-Nucleobase Modification for CRISPR. Clustered regularly interspaced short palindromic repeat (CRISPR) technologies have opened new scientific avenues widely used in biomedical research. However, simple and efficient strategies to reversibly control CRISPR are lacking. Tian Tian (田沺) and coworkers report a novel approach for regulating CRISPR systems using small molecules. They develop a strategy involving 4-(bromomethyl)phenylboronic acid that can be installed efficiently at nucleobases in guide RNAs. This allows the CRISPR system to be switched off and reactivated with hydrogen peroxide.

Cite this: CCS Chem. 2023, 5, 2933-2944

Link: https://doi.org/10.31635/ccschem.023.202202604

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-Polymer Solar Cells. The power conversion efficiency (PCE) of polymer solar cells (PSCs) has been increasing at a rapid pace. However, several critical issues, such as the cost of materials and the sensitivity of the PCE to active-layer thickness, must be addressed before industrial application can be realized on a large scale. Lei Meng (孟磊), Chenkai Sun (孙晨凯), Xiaojun Li (李骁骏), Yongfang Li (李永舫), and coworkers demonstrate a high-performance ternary PSC based on a low-cost polymer donor PTQ10 and an A-DA’D-A-type small molecule acceptor. Their work shows that PTQ10 is a highly promising photovoltaic donor material with low cost and high photovoltaic performance, that can drive the commercial application of PSCs forward.

Cite this: CCS Chem. 2023, 5, 2945-2955

Link: https://doi.org/10.31635/ccschem.023.202302720

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-Nanomechanics of Sub-nanowires. Sub-nanowires, ∼1 nm in thickness, possess an inorganic skeleton but display characteristics akin to those of carbon–carbon backbone polymers. Xun Wang (王训) and coworkers have employed AFM-based single-molecule force spectroscopy (SMFS) to study the mechanical properties of inorganic sub-nanowires. They show that combination of AFM-based SMFS and molecular simulation can reveal the structure–activity relationship of sub-nanowires at the molecular level.

Cite this: CCS Chem. 2023, 5, 2956-2965

Link: https://doi.org/10.31635/ccschem.023.202302729

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