下载客户端

对抗冠状病毒相关技术的专利检索（第4辑候选对症治疗方法）

2020-09-22 18:22

来源：澎湃新闻·澎湃号·湃客

原创丑丑姐姐专利分析可视化

本文介绍了可能对感染患者的SARS-CoV-2症状产生有益影响的小型有机分子/肽类抗病毒药物的相关专利的检索策略。由于研究正在迅速发展，因此，本文中所列的药物清单并不详尽。检索的目标文献是公开了这些特定药物的化学结构式以及具有相类似化学结构的相关文献。

检索使用的数据库为Espacenet。

1. Alpha-lipoic acidα-硫辛酸

Alphalipoic acid α-硫辛酸是一种存在于线粒体的辅酶，类似维他命，能消除导致加速老化与致病的自由基。硫辛酸在体内经肠道吸收后进入细胞,兼具脂溶性与水溶性的特性。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt ="Alphalipoic_acid*" OR ctxt = "lipoic_acid*" OR ctxt ="thioctic_acid*" OR ctxt = "thiogamma" OR ctxt ="tiobec") OR (claims = "dithio_octanoic*" OR claims ="Dithiolan*_3_pentanoic*") OR cl = "A61K31/385")

2. Anakinra

重组IL-1受体拮抗剂Anakinra可能有助于中和严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相关的炎症。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona_vir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "anakinra*" OR ctxt = "kineret*" OR ctxt ="kinaret*" OR ctxt = "antril*" OR ctxt ="raleukin*") OR cl = "A61K38/1793")

3. Baricitinib 巴瑞替尼

巴瑞替尼（Baricitinib）是一种是Janus(JAK1/JAK2) 激酶抑制药，由美国制药公司Incyte 和Eli Lilly共同开发，主要用于治疗成人中重类风湿关节。据推测，通过抑制JAK1和JAK2，baricitinib可以减少与这种感染并发症相关的细胞因子风暴（cytokinestorm）。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl = "A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt = "coronavir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "Baricitinib*" OR ctxt = "Olumiant*" OR ctxt ="INCB_028050") OR cl = "A61K31/519")

4. Cepharanthine 千金藤素

Cepharanthine千金藤素，是Biscoclaurine生物碱，抑制肿瘤坏死因子（TNF)-α介导的NFκB刺激，血浆细胞膜脂过氧化，及血小板聚集，且抑制细胞因子的产生。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl = "A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt = "coronavir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "Cepharanthin*" OR ctxt = "O_Methylcepharanolin*" OR ctxt = "SML_1269") OR cl = "A61K31/4745")

5. Dexamethasone 地塞米松

地塞米松是一种人工合成的皮质类固醇，可用于治疗多种症状，包含风湿性疾病，某些皮肤病、严重过敏、哮喘、慢性阻塞性肺病、脑水肿，也可能与抗生素合并用于结核病患者。初步临床试验结果显示，地塞米松可挽救新冠肺炎重症患者生命，对于使用呼吸机的患者，可将其死亡率降低约三分之一，对于仅吸氧的患者，可将其死亡率降低约五分之一。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona_vir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "De#amet?ason*" OR ctxt = "dextenza*" OR ctxt ="hexadrol*" OR ctxt = "de#ason*" OR ctxt ="decadron*") OR cl = "A61K31/573")

6. Eritoran

Eritoran具有抗流感的功效。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona_vir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "eritoran*" OR ctxt = "b_1287" OR ctxt ="E_5564") OR cl = "A61K31/7024")

7. Erlotinib

Erlotinib是一种EGFR抑制剂，用于治疗非小细胞肺癌。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt ="Erlotinib*" OR ctxt = "Tarceva*") OR cl ="A61K31/517")

8. Fedratinib

Fedratinib，是一种选择性JAK2抑制剂。Fedratinib有潜在的抗肿瘤活性。Fedratinib可抑制细胞增殖并促进凋亡。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt ="Fedratinib*" OR ctxt = "Inrebic*" OR ctxt ="TG_101348" OR ctxt = "SAR_302503") OR cl ="A61K31/506")

9. Fingolimod 芬戈莫德

Fingolimod芬戈莫德，为受体调节剂，临床上主要用于治疗复发缓解型多发性硬化症。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona_vir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "fingolimod*" OR ctxt = "gilenya*" OR ctxt ="FTY_720") OR cl = "A61K31/137")

10. Flutamide 氟他胺

Flutamide氟他胺，为非甾体类抗雄激素药物。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona_vir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "flutamid*" OR ctxt = "eulexin*" OR ctxt ="NFBA" OR ctxt = "niftolid*" OR ctxt ="SCH_13521") OR cl = "A61K31/167")

11. Fluticasonepropionate 丙酸氟替卡松

Fluticasonepropionate丙酸氟替卡松，为糖皮质激素类药，具有较强的抗炎和抗过敏作用。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt = "covid"OR ctxt = "cov") AND ((ctxt = "Fluticasone_Propionat*" ORctxt = "fl#nas*" OR ctxt = "flovent*" OR ctxt ="Flixonas*" OR ctxt = "flusonal*") OR claims=(Flixotid* ORFlutide* OR Flutivate*) OR cl = "A61K31/56")

12. Interferon 干扰素

Interferon干扰素，具有抗病毒、抑制细胞增殖、调节免疫及抗肿瘤作用。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl = "A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt = "coronavir*" OR ctxt ="sars_Cov" OR ctxt = "covid" OR ctxt = "cov") AND ((ctxt = "interferon*" OR ctxt = "plaferon*" OR ctxt ="CL_884" OR ctxt = "IFN*") OR cl = "A61K38/21")

13. Macrolides, e.g. azithromycin 大环内酯类抗生素，例如阿奇霉素

羟氯喹配合azithromycin阿奇霉素在抑制新冠病毒方面有效果。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl = "A61K45/06/low") AND (ctxt = "corona_vir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt ="azithromycin*" OR ctxt = "azithrocin*" OR ctxt ="zit?romax*" OR ctxt = "zitrim*" OR ctxt ="zitrotek") OR cl = "A61K31/7052")

14. Nimesulide

尼美舒利（Nimesulide）是一种非甾体类抗炎药，可用于慢性关节炎（如骨关节炎等）的疼痛、手术和急性创伤后的疼痛、原发性痛经的症状治疗。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt = "Nimesulid*"OR ctxt = "Aulin*" OR ctxt = "Me????sulid*" OR ctxt ="sulid#n*" OR ctxt = "flogovital*") OR (claims ="Lizepat*" OR claims = "Nicip*" OR claims ="Nimed*") OR cl = "A61K31/63")

15. Novaferon 乐复能

乐复能（Novaferon），通过IFN-α的DNA改组产生的新型重组蛋白，在体内和体外均显示抗肿瘤作用，用于乙肝治疗。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND (ctxt = "novaferon*"OR cl = "A61K38/21")

16. Ruxolitinib

Ruxolitinib一种激酶抑制剂，抑制Janus相关激酶(JAKs)JAK1和JAK2，介导对造血和免疫功能重要的若干细胞因子和生长因子信号，Ruxolitinib治疗骨髓纤维化的药物。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt ="Ruxolitinib*" OR ctxt = "Jakafi*" OR ctxt ="Jakavi*" OR ctxt = "NC_424" OR ctxt ="INCB_018424") OR cl = "A61K31/519")

17. Sunitinib 舒尼替尼

Sunitinib舒尼替尼，是一种新型多靶向性的治疗肿瘤的口服药物。

(cl ="A61K31/low" OR cl = "A61K38/low" OR cl ="A61K45/06/low") AND (ctxt = "corona vir*" OR ctxt ="coronavir*" OR ctxt = "sars_Cov" OR ctxt ="covid" OR ctxt = "cov") AND ((ctxt ="Sunitinib*" OR ctxt = "Sutent*") OR cl ="A61K31/404")

18. Ulinastatin 乌司他丁

Ulinastatin乌司他丁，是一种能抑制多种蛋白水解酶活力的糖蛋白，属蛋白酶抑制剂，临床上可用于治疗急性胰腺炎，慢性复发性胰腺炎，亦可用于急性循环衰竭的抢救辅助用药。